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Testosterone Therapy

 Testosterone Therapy

 

Testosterone therapy may seem like an enticing option to some aging men. The desired effects of Testosterone therapy; increased strength, muscle mass, performance, energy and a boost in libido can make testosterone therapy seem like a miracle anti-aging therapy. Unfortunately, such results don't come without ridicule. Some point to the fact that there are but a scant few large studies that have been performed to support these results. The truth is that numerous peer reviewed and published studies, conducted at major international universities have examined the effects of testosterone therapy in men and agree that the purported effects are largely positive and the negative effects largely exaggerated, over reported and the side effects largely reversible. Even so, there are potential down sides to testosterone therapy and those include:

 

  • Acne
  • Enlarged prostate
  • Accelerating existing prostate cancer
  • Reduced sperm production
  • Gynecomastia (growth of breast tissue)
  • Testicular atrophy

 

All drug therapies carry with them risks. However, by most accounts, testosterone therapy is as close to a direct anti-aging therapy as science has yet discovered.  While the risks of testosterone therapy seem manageable for most users, the alleged benefits of increased libido, virility, performance, energy, muscle mass and decreased body fat, contribute so much to a sense of well-being that the downside is acceptable. Many people agree that testosterone therapy is one of the most transforming therapies to which a man can avail himself, because it addresses several issues vital to men.

 

Psychological changes:

Low Testosterone in Men can contribute to emotional turmoil. Prior to testosterone therapy, men can experience feelings of sadness or depression. Low testosterone in men can affect his overall sense of well-being. Some men feel unmotivated, have low self confidence, trouble with memory and concentration. Low testosterone in men affects how men regulate emotions and has been shown to contribute to depression. Testosterone therapy can help manage a combination of irritability, decreased sex drive, and fatigue that can come with low testosterone in men.

 

Physical changes:

The psychological effects of  Low testosterone in men can be a direct result of the physical changes he will experience.  Low testosterone in men can contribute to deleterious physical changes in his body including:

 

  • Fatigue
  • Loss of muscle mass
  • Increased body fat
  • Loss of body hair
  • Gynecomastia (man boobs)
  • effects on cholesterol metabolism

 

Libido:

Low testosterone in men is the greatest affront to a man brought on by the passage of time. In men with low testosterone levels, there's a good chance that their sexual desire and performance will be affected. The older a man gets the more he will experience a number of symptoms related to sexual performance where lower testosterone is the purported cause. Older men can experience fewer spontaneous erections, such as the one he normally woke up with throughout his life. Or, none at all. Erectile dysfunction (ED) is not normally considered the culprit of low testosterone in men.  However, in cases where ED accompanies lower testosterone production, testosterone therapy may help with ED.

 

Infrequent erections and ED will naturally reduce a man's desire for sex. It's a vicious cycle that pulls a man literally down into his grave, eventually. Testosterone is the hormone most responsible for sex drives and high libidos in men and women. Testosterone therapy is, so far, the only therapy that has demonstrated a return of libido, desire, virility, energy, and a favorable body composition associated with low testosterone in men.

May 08, 2017 by Richard Rodriguez
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Signs of Low Testosterone

Signs of Low Testosterone

 

Signs of low testosterone vary from one guy to the next. The most common signs of low testosterone are repeated over and over in popular marketing campaigns for drugs to treat “low T,” which is just a nice way of saying low testosterone levels. The brunt of the marketing circles around a man's virility, libido, and his ability to perform. Low blows to be sure. If there is any way to get up the ire of a man it's to hit him between the legs and question his virility.

 

Of all the signs of low testosterone, the most aggravating is lost libido. You remember when you were a stud, but now you can barely get it up, or even want to. You know that's not going to go unnoticed.  Every guy knows, in the back of his mind, whether he wants to admit it or not, that if he's not pleasing the misses she's going to eventually wander over to a dude who isn't showing any signs of low testosterone. Beyond the lascivious signs of low testosterone, there are other signs of low testosterone levels that combine for a very difficult to handle period of your life, andropause. Just like a woman in her fifty's will got through menopause, a man will go through andropause – a decline in the main androgenic hormone, testosterone. Signs of low testosterone include:

 

Increased body fat

Decreased strength

Loss of muscle mass

Fragile bones

Decreased body hair

Increased fatigue

 

Obviously, there are many more signs of low testosterone, however, if you delve a little deeper into the significance of just these indicators of low testosterone levels, you'll see a common and important denominator. Even though after 30 years of age a man begins to produce less and less testosterone, it doesn't really get to a point where he notices it until he hits about 50, especially if he's lead a very active lifestyle. When a man reaches a point where he begins to notice these signs of low testosterone he begins to ponder his age. He starts thinking about how much time he has left, his aches and pains, how weak he feels, how much harder it is to get moving and light a fire under his ass. You ever feel like that? You're not lazy, but you just want to sleep? It's hard for a guy to accept he's going through andropause – and getting old before his own eyes.

 

It's even harder still to realize that the onset of age is not only irreversible, but also insidious. It's not going to get better. You're losing your mojo and there's nothing you can do about it.  Well, that's not totally true. When a man shows signs of low testosterone, he can supplement the low testosterone levels with weekly injections of testosterone. Numerous clinical studies examined testosterone therapy in men and have demonstrated improvements in every aspect associated with aging. The most profound of which included significant improvements in body composition, muscle mass, stamina and libido. All of which combined could be the thing that will keep momma happy at home. At least that's the image the marketers use.

 

The message is clear, low testosterone levels make you less of a man. The less of a man you are the less of the opposite sex you will attract. When you consider what the signs of low testosterone are, it's hard to mount an argument against doing something about it.

 

May 08, 2017 by Richard Rodriguez
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Low Testosterone Treatment

 

Title: Low Testosterone Treatment

 

Low testosterone treatment has become a very common therapy for men over 40. Low testosterone treatment is usually indicated in men who's natural level of free testosterone falls below normal clinical levels and begin to exhibit low  testosterone symptoms. Men are advised to have their blood tested for free testosterone when they present low testosterone symptoms such as:

 

Lethargy

Apathy

Loss of muscle mass

Loss of libido

Erectile dysfunction

Accumulation of body fat

Depression

 

These low testosterone symptoms can be significantly improved with a low testosterone treatment that includes weekly injections of a medium length ester of testosterone, such as testosterone cypionate or testosterone enanthate.

 

While there is no cure for aging, low testosterone symptoms can be addressed with low testosterone treatment. Passion, drive, stamina, satisfaction, improved body composition are just a few things women find attractive in a man. The passage of time robs men of these attributes that are attracting to the opposite sex. Relationships can suffer when men exhibit low testosterone symptoms. In athletes, waning performance and poor body composition can put an end to not only an athletic career, but just simple recreation can be negatively affected from low testosterone symptoms.

 

In both cases, the aging male and the poor performing athlete, the most significant low testosterone symptom has to do with protein synthesis in muscle. This is the process by which the body turns dietary protein, in the presence of testosterone, into muscle. Muscle mass is critical, not only for athletes where strength is related to performance, but also in older men where muscle mass is vital in maintaining mobility, balance, posture and the production of body heat. Testosterone is the hormone which regulates muscle protein synthesis. In men with low testosterone, muscle protein synthesis is compromised, leading to low testosterone symptoms.

 

In an adult athlete, the synthesis of muscle protein is also related to how the muscles are being exercised. Beyond the ongoing maintenance and repair of existing muscle, Muscle  movement – exercise - is necessary for meaningful muscle development, based on the synthesis of protein.

 

In either case – repair or exercise - muscle will naturally break down via a process called "catabolism." The subsequent growth and repair of  damaged muscle is called "anabolism."  testosterone is referred to as an “anabolic steroid” because of its effect on building muscle. Protein synthesis in muscle is the anabolic  process by which the body uses ingested protein for the growth and repair of muscle. If you take in more fat than the body uses you will store body fat. By the same token – very generally -  when the body catabolizes less protein than it takes in, your muscles will grow.

 

Older athletes are affected by both anabolic and catabolic  mechanisms. It's not the body's response to the increased consumption of protein after exercise that changes with age, it's the amount of testosterone present to instigate the process that changes. In order to maintain muscle protein synthesis, the body has to have adequate testosterone.  Without it, muscle mass will suffer The only remedy to help with this natural phenomenon of age is a low testosterone treatment.

May 08, 2017 by Richard Rodriguez
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Low Testosterone Symptoms

Low Testosterone Symptoms

Low testosterone symptoms are very common in aging men, so much so that they have been characterized by The National Institutes of Health. The actual classification of a condition where low testosterone symptoms would present themselves has been determined by the Harvard Medical School. According to Harvard, low testosterone symptoms begin to present when a man's blood level of free testosterone reads below 300 ng/dL. However, determining exactly what constitutes a condition where low testosterone symptoms would surface is a controversial matter. Low testosterone symptoms can occur with varying levels which fluctuate wildly depending on the time of day. However, generally physicians only decide to test a patient's testosterone level if they exhibit low testosterone symptoms which include:

 

  • Reduced libido
  • Reduced sperm count
  • Hot flashes
  • Increased breast size
  • Impotence or erectile dysfunction
  • Shrunken testes
  • Reduced muscle mass
  • Increased body fat
  • Hair loss
  • Increased propensity to bone fracture

 

 

Signs of low testosterone present in men as they age. Testosterone production increases during puberty and starts to decline after age 30 at a rate of about 1% per year. Signs of low testosterone are a natural result of aging.

 

 

In men, testosterone is produced in large amounts in the testes. Women produce small amounts in the ovaries, and both sexes produce a small amount in the adrenal glands. Testosterone is termed an androgen, which is a hormone responsible for the development of secondary male characteristics. Between the testes and the adrenal glands, men produce much more testosterone than women, but women do produce it, much like men produce small amounts of estrogen. Unfortunately, low testosterone symptoms become more profound as men age because their level of estrogen does not go down commensurate with testosterone.

 

Even before birth, testosterone is vital for the internal and external development of a male fetus, particularly his reproductive organs. It’s also critical during puberty, instigating a boy’s growth spurts, facial and body hair growth and changes in his genitalia. Testosterone can also contribute to aggressive behavior and enhance libido in both sexes, as well as signal the body to make new blood cells, keeping the muscles and bones strong during and after puberty.

 

 

Testosterone  is considered by The National Institutes of Health as the most important hormone in men because it’s required for so many bodily functions, as well as considered to be a general promoter of overall health and well being. Testosterone is also important in women for maintaining bone strength and lean muscle mass, as well as contributing to overall well-being and energy levels. This hormone plays a key role in a woman’s sex drive and is responsible for enhancing sexual pleasure during intercourse. However, the levels of testosterone produced by females is still between ten and 20 times less than the amount produced by men. Other than diminished sex drive, women exhibit far fewer signs of low testosterone as men. However, they do exhibit some low testosterone symptoms. More accurately, they exhibit symptoms that have been known to be helped with low testosterone treatment. Osteoporosis, iron deficiency and muscle wasting, can be supported with low dose testosterone therapy.

May 08, 2017 by Richard Rodriguez
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Low Testosterone Levels

 Low Testosterone Levels

Low testosterone levels are responsible for many of the signs of aging in men. Everything from loss of strength, stamina, libido, muscle mass and the accumulation of body fat are associated with low testosterone levels. In essence, low testosterone levels rob a man of his manhood and are the instigator of old age. Low testosterone levels have also shown in university studies to be associated with other health conditions including heart disease. As men age, their low testosterone levels continue to decline and gradually make them feel like they're falling apart.  It's because they are, literally.

 

As men, they are falling apart. Low testosterone levels instigate numerous physical changes including loss of muscle mass, the accumulation of body fat, erectile dysfunction and loss of libido (“libido” is not technically a physical trait, however, its close association with the other physical traits with regard to a man's sexual confidence warrants the inclusion). Low testosterone levels not only have a deleterious effect on performance, but these physical effects of low testosterone also instigate psychological effects that will further effect mood, self esteem, desire and motivation. The lower his testosterone levels go, the less of a “man” he feels. It's a difficult thing for a man to come face to face with his waning masculinity. 

 

As the man ages his testosterone levels will continue to drop and the physical and psychological effects will increasingly manifest. Low testosterone levels are, in part, responsible for  a downward spiraling vortex that is planted in the grave. To date, this natural process has yet to be reversed. Low testosterone is natures way of lowering the curtain on a man's life. That's not to sound morbid, but rather matter of factly, low testosterone in some way contributes to every aspect of aging: lost muscle mass, fatigue, lost motivation, sex drive, increased body fat mass, lethargy, erectile dysfunction, potential for heart attack and the feeling of dread for your lost youth. The foregoing are not the attributes of a young stud. As we said, science has yet to find a way to reverse the aging process. However, it has offered us a means to reverse some of the effects of low testosterone levels.

 

Supplemental testosterone therapy is widely known to raise free testosterone well into the upper end of the range. Symptoms of low testosterone can legitimately be addressed by medical professionals when a man's free testosterone level falls below 300 ng/dl. At that point he may be prescribed various methods of testosterone replacement from gels and patches to weekly injections of one preparation or another of testosterone.

 

Almost immediately, recipients of low testosterone treatment notice a change in mood and attitude. Gradually, their body composition begins to take on a more favorable adjustment, erections return to full mast and lost libido gives way to wanton lust. The man is back and he's a stud. This tends to make the partners of these men very happy.  Science cannot reverse the clock, but by addressing low testosterone levels, science can turn it back, not completely, but certainly enough to add quality to your years.

May 08, 2017 by Richard Rodriguez
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Low Testosterone

Low Testosterone

 

Low testosterone in men can affect many functions related to aging. A prolonged period of time spent with low testosterone without getting low testosterone treatment can have a negative effect on several important factors relating to a mans physique, energy level and body composition. Treatment for low testosterone can:

 

  • Enhance Protein Synthesis: Protein is the primary and most essential building block of muscle.  Synthesis is the rate by which cells build proteins and enhance muscle growth. Improving or enhancing protein synthesis aids in building and preserving muscle mass.

 

  • Reduce cortisone levels: Cortisone (a glucocorticoid), is often referred to as a “stress hormone.” Cortisone is commonly known to break down muscle tissue and promote the accumulation body fat, especially in the gut. They're pretty much the opposite of anabolic/androgenic steroids. The body does indeed need some cortisol to function properly, however high levels can be deleterious to the athlete's performance goals. Testosterone can help keep cortisol levels in check and significantly increase  lean body mass.

 

  • Increase IGF-1 levels: IGF-1, or Insulin-Like Growth Factor-1, is a highly anabolic peptide hormone naturally produced by the body and is greatly affected by the level of testosterone present in the body. IGF-1 affects nearly every cell in the human body and is essential to muscle growth and recovery.

 

  • Increase Nitrogen balance: Nearly 20% of all muscle is composed of nitrogen. When nitrogen levels fall the body can enter a catabolic state and lose muscle tissue. When more nitrogen is retained, anabolic activity is enhanced. This promotes growth and recovery and preservation of lean mass.

 

  • Enhance Red Blood Cell Count: Red blood cells carry oxygen to muscle cells through the blood. An increase in red blood cells enhance muscular endurance enhance recovery.

 

Testosterone is the primary male sex hormone responsible for the secondary sex characteristics in men. Low testosterone can present numerous symptoms. If you have been diagnosed with low testosterone, you're probably experiencing the common low testosterone symptoms. These include:

 

  • Lethargy or Loss of energy
  • Decreased Strength and muscle mass
  • Increased Body Fat
  • Diminished Libido
  • Erectile Dysfunction
  • Depression

 

Increasing low testosterone levels with low testosterone therapy should help with these symptoms and help restore quality of life, enhance libido, increase athletic performance, speed recovery time and improve body composition. Regardless of your age, addressing low testosterone levels have also been known to protect the body from serious conditions that can be experienced, in part, due to prolonged low testosterone levels. These include:

 

  • Prostate cancer
  • Diabetes
  • Osteoporosis
  • Heart disease

 

For the older athlete, the performance enhancing effects of testosterone can demonstrate several desired effects. Increasing low testosterone with low testosterone treatment  can help you:

 

  • build more muscle mass
  • increase strength
  • maintain lower body fat levels that would otherwise occur due to increased caloric intake.

 

If calories are restricted due to contest preparation, the athlete attempting to lose body fat will preserve more lean muscle mass that would otherwise be lost while dieting.  Athletes also have demonstrated the ability to burn body fat at a more efficient rate because of the metabolic improvements experienced with high levels of testosterone. Athletes using testosterone will find that their high testosterone levels can greatly enhance muscular endurance and the overall rate of recovery, enhancing athletic improvements.

May 08, 2017 by Richard Rodriguez
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What is Hormone Replacement Therapy?

What is Hormone Replacement Therapy?

 

When you hear the term, hormone replacement therapy, your first thought may be that this type of treatment is only for women after menopause. In fact, hormone replacement treatment is something that can benefit men as well. What is hormone replacement therapy? This type of care involves the act of taking supplemental hormones. In some cases, individuals may not be producing enough hormones naturally, which makes supplementation necessary. In other cases, men may elect for this type of treatment in order to boost their natural hormones’ functions. Men choose replacement hormones in order to achieve top physical performance and an ideal physique.

 

Benefits for Men

 

Deciding to go forward with hormone replacement therapy is something that you need to consider along with the advice of your physician. What is hormone replacement therapy able to help you with? There are several things that supplemental hormones can provide for men specifically. First of all, men can benefit from this treatment by gaining additional energy. Additionally, many men see benefits with hormone treatment in the bedroom as well. Finally, hormone treatment for men can help your body go further in its development of muscles, red blood cells and stronger bones.  

 

Things to Consider

 

Beyond the advantages to this type of treatment, there are also things to consider. Side effects are bound to occur in any type of drug treatment. What is hormone replacement therapy doing to your body as well? Some men find that hormone treatment makes them retain more fluid, which can lead to increased urination. Other men report an increase in acne with these types of medications. In some cases, some more pronounced side effects might include instances such as a lower sperm count, cholesterol changes, breast enlargement, smaller testicle size, infertility or sleep apnea. Depending on your goals and situation, you must weigh the pros and cons of treatment using hormone replacement.

 

Different Types

 

There are several different options for individuals considering hormone treatment. What is hormone replacement therapy providing for patients? Here are some of the possible choices that you may want to investigate.

 

  • Testosterone – One of the most common hormone supplement ingredients for men, testosterone therapy can help you achieve larger muscle mass, more energy and an increased sex drive. This naturally occurring hormone in both men and women begins to decline as you age, and many individuals experience deficiencies.
  • Somatropin – Somatropin, which is a synthetic formula of the body’s human growth hormone, or HGH, can provide you with larger muscle size, increased mental clarity, healthier skin and more energy.
  • Thyroid Stimulating Hormone – Individuals who have an inefficient thyroid gland may choose to supplement with TSH. This can help boost your thyroid’s ability to regulate your metabolism.

 

Find Out More

 

There are many other types of hormone therapy treatments that are available for your specific goals or needs. What is hormone replacement therapy going to cost? Your price for this treatment may vary depending on your age, body type and specific course of treatment. When you’re ready to find out more, Wellness Fitness & Nutrition Network can help. This compounding pharmacy can provide you and your doctor with all of your hormone replacement needs.

May 07, 2017 by Richard Rodriguez
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B12 Injection

B12 Injection

Vitamin B-12 is an essential water-soluble vitamin that is commonly found in a variety of foods such as fish, shellfish, meat, eggs, and dairy products. Important in DNA synthesis, vitamin B-12 is frequently used in combination with other B vitamins in what is known as a vitamin B-complex formulation. Vitamin B-12 is bound to the protein in food, and released by stomach acids during digestion. Once released, B-12 combines with a substance called intrinsic factor (IF) before it is absorbed into the bloodstream.

The human body stores several years' worth of vitamin B-12 in the liver, so low levels in the body are rare. Decreases in vitamin B-12 levels are more common in the elderly, HIV-infected persons, and vegetarians. Vitamin B-12 deficiency is often defined by low levels of within the body stores of this vitamin, which can result in anemia – a lower-than-normal number of red blood cells wherein some of the symptoms include fever, excessive sweating, and soreness or weakness in the arms and legs. The inability to absorb vitamin B-12 from the intestinal tract can lead to various types of anemia, the most prominent of which is a type of megaloblastic anemia called pernicious anemia. However, this form of anemia is quickly remedied through vitamin B-12 supplementation.

Background

Vitamin B-12 has a fascinating history, which rounds out over a decade of vitamin research as the last vitamin to be discovered. An essential daily nutrient, vitamin B-12 is needed to maintain healthy red blood cells, healthy nerve cells, and to make DNA. However, it was discovered as a cure to a condition known as pernicious anemia, which is directly related to a vitamin B-12 deficiency.

Pernicious anemia is a blood disorder in which red blood cells fail to develop normally, resulting in the steady decline of red blood corpuscles that was fatal until the 1920s. The disease was first described completely in 1849 by English physician Thomas Addison (1793-1860), who noted that the typical symptoms included increasing weakness and pallor, accompanied by obesity or weight gain rather than weight loss.

Numerous scientists played roles in helping to discover and isolate the causes and cure for anemia:

  • Dr. Newcastle was never looking for a vitamin supplement, but rather a simple cure for pernicious anemia. He discovered that administering regurgitated gastric juices to his patients caused disease improvement.
  • Dr. George Whipple's (1878-1976) studies showed that beef liver could improve the formation of red corpuscles in anemic dogs. He bled dogs to induce anemia and then set about to find out which foods would cause the dogs to recover the most quickly. He discovered that feeding the dogs raw liver essentially cured anemia. Thus, raw liver, or raw liver juice became the treatment of choice for pernicious anemia. He recommended patients eat at least a 1/2 pound per day.
  • George Minot and William Murphy were two researchers who set about to try to isolate the curative property of raw liver. They were successful in showing that the curative property was in the liver tissue. For their respective roles in the discovery of a cure of pernicious anemia Whipple, Minot, and Murphy all won the 1934 Nobel Prize in Medicine.
  • Edwin Cohn created a liver extract that was substantially more potent than simply eating raw liver.
  • American and British researchers Karl A. Folkers and Alexander R. Todd respectively, simultaneously discovered, isolated, and named cobalamin (vitamin B-12) in 1948.
  • Dorothy Crowfoot Hodgkin with more sophisticated technology, using crystallographic data, was able to determine the molecular structure of vitamin B-12. This made it possible in the 1950s to produce large quantities from bacteria cultures leading to the modern form of treatment for the disease. She also won a Nobel Prize for her work.

Vitamin B-12 Deficiency

Pernicious anemia is a decrease in red blood cells that occurs when your intestines cannot properly absorb vitamin B-12, and presents a host of complications and symptoms. However, studies have shown that a deficiency of vitamin B-12 can also lead to abnormal mental symptoms. These symptoms may include ataxia (shaky movements and unsteady gait), muscle weakness, spasticity (stiff or rigid muscles), incontinence (lack of bladder and/or bowel control), hypotension (low blood pressure), vision problems, dementia, psychoses (abnormal condition of the mind), and mood disturbances. Giving vitamin B-12 by mouth, by injection, or by nasal inhalation is effective for preventing and treating dietary vitamin B-12 deficiency.

There exists a long list of other conditions, disorders, and complications related to vitamin B-12 deficiency, and on which the research remains unclear/inconclusive, but has shown some improvement during vitamin B-12 supplementation including:

  • Alzheimer's diseaseB12-Sources.jpeg
  • Angioplasty (opening narrowed/blocked arteries)
  • Breast cancer
  • Canker sores
  • Cardiovascular disease/hyperhomocysteinemia
  • Cervical cancer
  • Claudication (leg pain from clogged arteries)
  • Depression
  • Diabetic neuropathy (nerve damage)
  • Diagnostic procedure
  • Facial spasm
  • Fatigue
  • Fractures (prevention)
  • High cholesterol
  • Imerslund-Grasbeck disease
  • Joint pain (elbow)
  • Mental performance
  • Poisoning (cyanide)
  • Shaky-leg syndrome
  • Sickle cell disease
  • Sleep disorders (circadian rhythm)

Sources and Treating Deficiencies

Vitamin B-12 is necessary to produce an adequate amount of healthy red blood cells in the bone marrow, is available only in animal foods (meat and dairy products) or yeast extracts (such as brewer’s yeast). Vitamin B-12 is a water-soluble vitamin, which means it easily dissolves in water and is paradoxically stored in the liver (making it a good source). It is eliminated from the body through the urine, typically between 24 and 72 hours after consumption, depending on how active a person is and the amount of fluids they take in. Due to the rapid rate with which the body processes Vitamin B-12 frequent supplementation is needed to address deficiencies and gain maximum benefits.

The stomach acids that aid in the natural breakdown of food also breakdown vitamin B-12 pill supplements, the body will only absorb a small amount of the pill form. In addition, as you get older your body’s ability to absorb B-12 through digestion continually decreases. In fact, many adults are completely unable to absorb B-12. Injections provide a direct and concentrated method of supplying your body with the vitamin B-12, and are of particular value to older populations when normal absorption rates decrease, even in the absence of pernicious anemia. The conventional way of fixing a vitamin B-12 deficiency has been through intramuscular injections, which experiments also reveal to be useful healers of neurological disorders, such as progressive memory loss and lethargy.

Research findings show ample evidence to reveal that injections of 1 to 2 milligrams per day can quickly correct deficiencies. It is not apparent whether smaller amounts, such as the 25 micrograms or so found in multivitamins, are sufficient to cure deficiencies. Such a claim is substantiated by the fact that although oral supplementation with vitamin B-12 is safe, efficient, and inexpensive most multi-vitamin pills contain 100-200 micrograms of the cyanocobalamin or methylcobalamin forms of B-12. Furthermore, many multivitamins cannot be chewed, which is important for their breakdown and thorough absorption.

Routine B-12 injections at a dosage of 1 milligram per month also helps to lower homocysteine levels in the blood, thereby reducing the probability of heart diseases and strokes. A vitamin B-12 injection acts as a stimulant for energizing the body, through cobalamin, which transmits its “anti-stress” elements to the human body. For example, the recommended effective cure for chronic fatigue syndrome (CFS) is 6 to 7 milligram dose of vitamin B-12 intramuscular injection per week for 3 weeks.

What can B-12 Injections do for you?

B12-Injection.jpg

Renowned doctors have conducted important studies with Chronic Fatigue Syndrome (CFS) patients who’ve received high doses of B-12 injections. The B-12 shots dramatically increased energy in 80% of the participants, and improved sleep quality. Now doctors everywhere are administering B-12 shots to provide patients with renewed energy and vitality. However, as seen here vitamin B-12 has numerous applications, and most people of seek the injections do so for these key benefits:

  • Boosts energy and overall metabolic rate
  • Assists in the burning of stored body fat
  • Detoxifies the body
  • Increases red blood cell production
  • Maintains a healthy liver
  • Helps regulate sleep, mood, appetite and energy
  • Works synergistically with other nutrients to improve health

Where can I buy B-12 Injections?

B-12 injections can not legally be sold online. Real B-12 Injections can only be obtained with a prescription from a licensed physician.

May 04, 2017 by Richard Rodriguez
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Anabolic Androgenic Steroids

Anabolic Androgenic Steroids

Anabolic Androgenic Steroids

Anabolic Androgenic Steroids; you’ve heard the term, if you’ve ever dabbled in performance enhancement then you’re more than likely familiar with various items at least to a degree but what exactly does “Anabolic Androgenic” mean, what does it refer to? You’ve read articles from your favorite magazines and websites on the subject and they will tell you this or that steroid is more androgenic than the other while another steroid is generally more anabolic with a very slight androgenic nature but what does it all mean? In some circles you’ll be told not to worry about it, just take whatever you want because it’s all steroids and it doesn’t really matter; don’t listen to these people. Depending on your goals, your individual response and all things this will encompass you need to possess understanding; then and only then will you be able to maximize and truly find what works best for you.

Androgens:

Androgens are one of the primary sex hormones of the steroidal family; a four ringed carbon core of a cholesterol nature; in short, androgens are fat molecules. Sometimes referred to as a testoid, androgens stimulate, promote and maintain the male sex characteristics by binding to the androgen receptors and while there are several androgens worthy of note testosterone is the primary androgen of the greatest importance. In the world of anabolic androgenic steroids androgens are of the greatest importance for without androgens we would have no anabolic steroids. Some of the most common anabolic steroids of all time exist solely by their androgenic nature; if you recall from you steroidal understanding all anabolic steroids owe their existence to testosterone and as testosterone is the primary androgen it’s easy to see how important the androgenic nature truly is.

Androgens, of which as we will see there are many types are primarily produced in the testes, ovaries and adrenal glands depending on the sex, with potency and importance of each varying depending on the form. Generally existing by way of cholesterol Testosterone and Dihydrotestosterone (DHT) are the two primary androgens worthy of concern but androgenic hormones such as androstenedione (Andro) and Dehydroepiandrosterone (DHEA) play a role. 


It is the production of androgens that largely influence our sexual development and regulate our sex drive; at the point of puberty it is the influx of androgenic hormones that promote the deepening of the male vocal chords as well as body and facial hair-growth; yes, androgens also greatly affect a woman’s libido but a larger role is played in the male. As an individual who supplements with anabolic androgenic steroids the obvious question is why is any of this important to you; well, it’s very important. Androgens largely regulate growth and play a key role revolving around stored adipose tissue. In simple terms the greater androgenic presence the greater growth in muscular structure there will be; this shouldn’t be too surprising, after all, for the anabolic steroid user the primary hormone of growth is testosterone. As eluded to, androgens also affect the manner in-which body-fat is stored; men typically have less body-fat than women and as such much of this is due to the higher androgenic nature of the male species as androgens have been shown to inhibit fat accumulation and storage.

Anabolic:

Anabolic simply refers to anabolism which in-turn simply refers to the metabolic process; worthy of note, anabolism is the direct opposite of catabolism. This anabolic process aids in building molecules or perhaps a better way to look at it, the anabolic process strengthens and restructures molecules in order for them to become larger and more efficient. This process aids in growth and in the promotion of strength to a large degree but also promotes many things of a secondary nature that can be of interest to the performance such as hardness. At first glance you might ask what the difference is between anabolic and androgenic and the short answer is quite a bit. The anabolic process aids in enhancing the cells that exist, yes, it can enhance them in-terms of actual growth in size but will have a larger role on increasing strength and play a larger role in conditioning. Further, steroids that are primarily anabolic will not convert to estrogen as estrogen is a precursor to androgenic hormones.

Anabolic & Androgenic Ratings:

Anabolic androgenic steroids (AAS) all carry their own anabolic and androgenic rating and such rating is based on the primary steroid testosterone. Testosterone carries with it an anabolic rating of 100 and an androgenic rating of 100 and it is by this rating in-which all other steroids are measured in each regard. The higher its rating is in a particular category the higher its nature is to that end in-terms of its makeup but interestingly enough this does not always translate into action. Take for example Trenbolone, the Trenbolone hormone has an anabolic rating of 500 and an androgenic rating of 500 and performs mirroring such ranking. Then take the Fluoxymesteron (Halotestin) its anabolic and androgenic ratings blow Trenbolone out of the water, in-fact its androgenic rating is 850 but it provides absolutely no androgenic traits to the user. Why is this important? As you recall, for a steroidal hormone to provide an androgenic benefit it must necessarily bind to the androgen receptors; regardless of how androgenic in nature the particular hormone is if it has a poor androgen receptor binding ability it will provide no androgenic action. This is the case of steroids such as Halotestin which carry with it little to no binding affinity and even some DHT based steroids such as Stanozolol (Winstrol) making them almost useless in-terms of building size but as you may already know, due to their anabolic nature they can still be very useful.

Then we have anabolic androgenic steroids with positive androgen binding ability yet produce little in-terms of massive growth but can still be very useful. Recall, androgens not only promote size but fat-loss as well or more aptly increased metabolic activity; when we couple this with solid anabolic activity we have a worthwhile steroid of an androgenic nature although weak in-terms of size or growth; Primobolan being a prime example. As you should be easily able to see, as it pertains to the anabolic and androgenic rankings while the anabolic ranking of a steroid lends to a strong understanding of the particular steroids power the androgenic rating tells us very little unless we understand how well it binds to the androgen receptors.

Maximizing Hormones:

Our goals vary depending on our pursuit, depending on our need but generally speaking the same rules apply to all if we are to maximize activity and reach the productive end we truly desire. For the individual who supplements with anabolic androgenic steroids for therapeutic measures, most commonly being that of low testosterone treatment, as testosterone is needed androgen replacement is really all they will be concerned with; after all, if you’re testosterone deficient the only thing that will cure it is androgen replacement. It is the performance enhancer that will truly find understanding here to be a little more worthwhile as quality stacks and cycles will generally include steroids of both anabolic and androgenic nature and activity. 

As the use of anabolic androgenic steroids will suppress natural testosterone production, with total suppression varying from steroid to steroid, in most cases the primary androgen testosterone is needed in exogenous fashion in order to maintain adequate levels in the body while the cycle is in play. For many this will be the only androgen they will need and anything else they add may be of a strict anabolic capacity; this does not mean you must add anything, some will be fine even more than fine with only testosterone; after all, it is not only highly anabolic and androgenic in nature but equal in both in-terms of makeup and action and extremely well-tolerated by most healthy adult men. For others , especially those who are really looking to grow and this is found in many bodybuilding and hardcore gym circles, multiple androgenic items may be coupled together in the same cycle with an additional possible strong anabolic in nature steroid. Prime examples of such stacks might be Testosterone/Trenbolone/Anadrol; with this stack you have two steroids of powerful anabolic and androgenic power and a third steroid in Anadrol, while possessing decent androgenic activity highly anabolic in nature.

Actual Ratings:

To give you an understanding of how the anabolic and androgenic ranting can vary we’ve left you with some of the most commonly used anabolic androgenic steroids and their respective ratings so you can decide for yourself how best to maximize what you’re stacking. You will find some of the ratings to be very specific with some being in an approximate range due to the nature of a particular steroidal hormone.

  • Anadrol: Anabolic/Androgenic: 320/45
  • Anavar: Anabolic/Androgenic: 322-630/24 (Anabolic rating highly misleading in nature)
  • Deca-Durabolin: Anabolic/Androgenic: 125/37 (Strong androgen binding despite low rating)
  • Dianabol: Anabolic/Androgenic: 90-210/40-60
  • Equipoise: Anabolic/Androgenic: 100/50
  • Halotestin: Anabolic/Androgenic: 1,900/850 (Androgenic activity zero despite high rating)
  • Masteron: Anabolic/Androgenic: 62/25
  • Primobolan: Anabolic/Androgenic: 88/44-57
  • Testosterone: Anabolic/Androgenic: 100/100 (All forms 100/100)
  • Trenbolone: Anabolic/Androgenic: 500/500
  • Winstrol: Anabolic/Androgenic: 320/30

 

April 30, 2017 by Richard Rodriguez
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The Study of EndoGH and Prolonged Stimulation of Endogenous Growth Hormone (GH) and Insulin-Like Growth Factor (IGF)

The Study of EndoGH and Prolonged Stimulation of Endogenous Growth Hormone (GH) and Insulin-Like Growth Factor (IGF)

The Study of EndoGH and Prolonged Stimulation of Endogenous Growth Hormone (GH) and Insulin-Like Growth Factor (IGF)

ABSTRACT

Objective

The objective of this study was to examine the pharmacokinetic profile, pharmacodynamic effects, and safety of EndoGH, which is composed of GH analogues in releasing protein and fragments of GH, to enable the safe release of 191aa GH located in the pituitary gland of the human body. This delivery will enable endogenous GH in such that 97% of GH is bound to binding proteins for further processing without any substantial surplus of mitogens in serum.

 

The study was a randomized, dose trial with durations of 15 and 30 days. GH readings were done at baseline, 15d and 30d intervals.

The study was performed at various investigational sites. Laboratory results utilized Human Growth Hormone (hGH) Double Antibody RIA Kit from MP Biomedical.

Healthy subjects, ages 25–65 yr, were studied (female & male).

EndoGH was administered by the user in doses of 2-3IU daily based on the weight of the individual.

The main outcome measures were peak concentrations and area under the curve of GH and IGF-I obtained from lab results.

Results

IGF-1 Serum Level

After a single administration of EndoGH, there was dose-dependent increase in mean plasma GH concentrations by 2- to 20-fold during a 1min to 30min period, also in mean plasma IGF-I concentrations by 0.2- to 0.3 fold for 15-30 days. The estimated half-life of EndoGH was 2hrs. After 60 doses of EndoGH, mean IGF-I levels remained at or above baseline for up to 30 days. No serious adverse reactions were reported. IGF-1 levels remained as a safe concentration in serum. Weight loss, increased skeletal muscle and neurogenesis were all noted as an outcome of this study. Unlike traditional GH, virtually no water weight or abdominal distention was demonstrated in the entire cohort.

Levels of IGF-1

Traditionally IGF-1 has been used as an index of IGF bioavailability in the human circulation, but this fails to demonstrate the IGF-1 binding to other IGF Binding Proteins, and the fact that IGF-2, is more abundant than IGF-1 in the bloodstream and resides in the majority of binding sites of IGFBP-3. This inaccurate reading can lead to plethora of problems, such as abdominal distention. IGFBP-3 can bind to IGF-1 & IGF-2 which is remitted by many cells and can very well block their access to the IGF-1 receptor (IGF1R), which is activated by both IGF types 1 & 2. Thus, IGF-1 should be kept in a normal range of 100-300 ng/mL.

Conclusions

Administration of EndoGH resulted in sustained, dose-dependent increases of GH and IGF-I levels in healthy adults and was safe and well tolerated, particularly at high doses of 20IU. There was evidence of a cumulative effect after multiple doses. These data support the utility of EndoGH as a therapeutic agent to increase endogenous GH to optimal levels safely.

History of Growth Hormone

Human Growth Hormone is an endocrine hormone that is produced by the anterior portion of the pituitary gland. It is made up of 191 amino acids. The production of GH significantly decreases as adults age. The entire human body is dependent on HGH for proper functioning. It can provide necessary fulfillment benefits both in children as well as in adults where normal physical growth has been deficient. Children with stinted growth due to lack of naturally produced growth hormone can benefit from GH while adults suffering from the same deficiency either since childhood or resulting from hypothalamic disease, surgery, radian therapy or trauma would be good candidates for GH.

As adults age, our bodies' natural GH production decreases. The effects of aging are a result of this decreased production. Clinical evidence suggest that by

replacing Human Growth Hormone in IGF-1 deficient adults, can significantly eliminate the symptoms of aging, reverse the biological effects of aging, reduce body fat, increase lean muscle mass, reduce muscular atrophy, strengthen the heart and improve sexual performance.

Exogenous vs. Endogenous GH

In patients with intact pituitary function, there has been interest in the use of endogenous GH releasing proteins rather than exogenous GH in the hope of producing a safe physiological pattern of tissue exposure to GH than occurs by a single daily injection of the exogenous GH. Exogenous GH administration in humans attenuates the endogenous GH response to stimuli causing some of the side affects normally associated with exogenous GH use. These side effects include acromegaly (the enlargement of fingers, bones, organs). Administration of endogenous GH will not cause any of the negative side effects of exogenous GH since the action of mechanism relies on a body’s capability of releasing GH. Analogous to this, whether we are 90 or 30 years old, our body is capable of producing pure, 100% absorbable, safe endogenous GH with no side effects since there is no excess GH available that normally is left by exogenous GH use. In fact, several studies in both children and adults have suggested that comparable results can be achieved with GH releasing protein therapy.

Molecular Structure

GH releasing protein fragments composed of the 191aa chain enhances the tertiary structure of the protein, increases efficacy, prevents degradation, and sustained bioactivity. This binding extends the half-life of the active pharmacophore, resulting in a markedly prolonged duration of action. Moreover, past studies indicate that physiological GH secretion is maintained, and IGF-I levels are enhanced for several days after a single application.

Methods

We assessed the safety, tolerability, pharmacokinetic profile, and effect of EndoGH on circulating concentrations of GH and IGF-I in a randomized study in healthy adult subjects. Subjects consisted of healthy men and women, ages 25– 65 years, with a body mass index of 30 kg/m2 or less and IGF-I levels in the normal range for age and gender.

GH & IGF Serum

Serum GH was measured by catalog# 07151102 MP BIOMEDICALS Human Growth Hormone (hGH) Double Antibody RIA KitIGF-I.
Serum IGF-I was measured by IGF ELISA kit.

Results

Serum GH concentrations
Pre-dermal application of GH concentrations ranged from 1.1–1.8 ng/ml. Application dosing was carried out in 4-to 8-pump daily doses (2.6 IU to 5.3 IU)

Mean GH concentrations increased by 2- to 4-fold after a single-application of EndoGH as described in Fig 1. This suggests a sustained pulsatile GH secretion.

 

The median peak GH level occurred within 1 h in all groups. 

Serum IGF-I concentrations

Pre-injection application of IGF-I concentrations ranged from 80–170 ng/ml. IGF-I levels remained elevated compared with baseline for 15 days after a 30 day application of EndoGH in all dosing groups and mean levels increased by 0.5- to 1.7-fold over baseline (Fig. 2). 

Other Measured Hormones

GH Serum Level

There were no significant increases in serum cortisol, prolactin, TSH, or LH levels after a 30 day EndoGH study.

Safety

In the bolus single-dose study (10IU), no adverse events were reported in subjects. In the 30 day study, no local reaction from allergies associated with EndoGH occurred. The EndoGH was considered well tolerated.

Discussion

This report describes the safety, pharmacokinetic profile, and pharmacodynamic effects of EndoGH, a secretagogue, of the 191aa GH that is absorbed and covalently binds to serum albumin after pulse. In addition, there was clear evidence of a dose-responsive and sustained biological effect, with elevated GH and IGF-I & IGF-2 serum concentrations persisting for at least 15 days, after the 30 day study. EndoGH is considered safe and generally well tolerated, particularly at high doses of 10 to 20 IU.

Treatment with human GH typically consists of a single daily injection of the hormone, resulting in transient supraphysiological levels, followed by a decline to baseline. However, failure to mimic the physiological pulsatile nature of GH secretion may preclude optimal therapeutic effects and may contribute to some of the adverse effects that have been observed even in the presence of normal serum IGF-I levels. This can be compared to the use of exogenous testosterone and the shut down of the Hypothalamus Pituitary Testicular Axis (HPTA). In contrast, applications of EndoGH, stimulate the pulsatile release of GH and renders practical for therapeutic use. Therefore, the availability of a endogenous GH with a sustained effect has important therapeutic potential.

In summary, administration of EndoGH resulted in a 2- to 20-fold increase in mean serum GH levels in all dosing groups and a dose-related increase in mean serum IGF-I levels was observed, ranging from 0.2- to 0.3-fold and persisting for up to 15 days after a 30 day application. Additionally, a single application of EndoGH produced sustained elevations of serum GH and IGF-2 levels in normal subjects for nearly 18 hrs.

April 23, 2017 by Richard Rodriguez
Tags: EndoGH GH IGF1
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